FAQs about Impryl

What is Impryl?

Impryl is a dietary supplement specifically formulated to support normal physiological maturation of sperm cells.

What does Impryl look like?

Impryl is presented as film-coated tablets packaged in high quality aluminum/PVC blisters that preserve integrity throughout their shelf life. Each box contains 2 blisters of 15 tablets each: a total of 30 tablets.

What are the active ingredients in Impryl?

Impryl contains all the substances needed to activate the two main metabolic pathways supporting sperm maturation: the transsulphuration pathway leading to the synthesis of glutathione, the universal cellular antioxidant, and the one carbon cycle – the main process sustaining cellular growth and differentiation.

The ingredients of Impryl are in the form of activated micronutrients. This means that the metabolic support of these micronutrients is available, even in those patients who do not have the capability to convert normal dietary micronutrients in to an activated form. Such individuals will be unaware of this deficiency, but it could be more than 25% of the population. Impryl contains chelated (bioavailable) zinc, several group B vitamins (B2, B3, B6, B9, B12), which are the necessary co-factors for key enzymes and a cysteine donor that is essential for the synthesis of glutathione.

A list of the active ingredients of Impryl is below:

Ingredient per day (1 tab) % NRV
Betaine 200 mg
L-cystine 200 mg
Niacin 16 mg 100
Zinc 10 mg 100
Vitamin B6 1.4 mg 100
Riboflavin 1.4 mg 100
Folic acid (5MTHF – glucosamine) 400 mcg 200
Vitamin B12 (methylcobalamin) 2.5 mcg 100

NRV: nutrient reference value according to Reg. (EU) n. 1169/2011.

Who should take Impryl?

Impryl is recommended for all men and women who are attempting to conceive, whether or not fertility problems are known. Environmental stress and modern lifestyles can negatively affect gametes in all individuals; it is, therefore, essential that they have adequately maintained defences. Several of the substances provided by Impryl do not have body reservoirs and temporary deficits may occur even in subjects who usually enjoy a balanced diet. Especially in men the weakened defence, albeit temporary, has the potential to negatively affect spermatogenesis.

Supplementation with Impryl is especially important in men with known sperm defects, seen in a standard spermiogram. In addition, you may be suffering from a specific defect, called sperm nuclear decondensation. Men with a sperm DNA Fragmentation Index (DFI) and/or Sperm Decondensation Index (SDI) higher than 20% have a reduced chance of conceiving and may require a longer course of supplementation with Impryl. Clinical data have shown that male partners of couples resistant to Assisted Reproduction Technologies (ART) may achieve a pregnancy if their DFI and/or SDI is reduced, as can be achieved with Impryl.

Supplementation with Impryl is also particularly promising in women with advanced reproductive age that are particularly susceptible to oxidative damage and in women with Policystic Ovary Syndrome (PCOS) that exert a specific weakness in the one carbon metabolism, which is supposed to be causal to their insulin resistance, hyperandrogenism and ovulatory disturbances.

What are the effects of Impryl on general health and well being?

Impryl contains nutritional supplements in balanced amounts; it is not expected to exert any pharmacological activity. If your diet lacks these substances, you will get a direct benefit, otherwise it is simply added nutrients.

People treated with Impryl enjoy a reduction in their circulating homocysteine, a metabolic end-product, which is usually recycled into a harmless form. Elevated homocysteine can be a health risk associated with disease states, including cancer and cardiovascular disease. Homocysteine recycling is essential for all cells and especially for proper sperm maturation. The effect of Impryl on homocysteine recycling positively influences health beyond the beneficial effect on sperm cells.

How long will I need to take Impryl?

In order to achieve optimal sperm in the ejaculate the male partner should have been taking Impryl for at least 3 months. In order to maintain the quality of sperm, he should continue to take Impryl.

In men, the recommended course of treatment is based upon the amount of time it takes for sperm to be produced. Production and maturation is a long process.

In women, the recommended course of treatment is based upon the amount of time it takes for a cohort of follicles to develop until the ovulation occurs, which is 3 cycles, i.e. roughly 3 months.

How much Impryl should I take?

The stated dose of Impryl is one tablet per day. This corresponds to normal physiological requirements of the active ingredients within an otherwise balanced diet.

How should Impryl be taken?

The tablet should be swallowed with water. This can be done at any time during the day, but we advise that you do so at the same time every day so that it becomes routine and your metabolic support is regular and predictable.

If possible, the tablet should be taken between meals because this will increase the bioavailability of the water-soluble substances.

What should I do if I forget to take Impryl?

Impryl is a nutritional supplement to be taken as part of a well balanced diet. Skipping a dose does not constitute a problem. Should it happen, just continue your dosing as scheduled. Should you forget several doses, just resume your normal pattern as soon as possible. Taking larger doses at one time would be ineffective at compensating for previously skipped doses.

However, there is a clear-cut dose effect so taking a dose that is far lower than suggested may reduce your benefit from the treatment.

Shall I take Impryl together with other nutritional supplements?

In general terms yes, at least as far as they are real nutritional interventions.

We strongly discourage taking Impryl together with strong direct antioxidants such as vitamin C, CoQ10 and selenium.

These substances may induce so-called reductive stress that might nullify the benefit from the gentle and physiological metabolic activation we are targeting. Strong antioxidants have been shown to cause an increase of the sperm decondensation index (SDI), which is very bad for male fertility potential. Moreover, while taking Impryl, you are already fully supported in your antioxidant capacity and no additional antioxidant activity is required.

Do I need a prescription for Impryl?

Impryl is a dietary supplement and does not necessitate a medical prescription. However, if you are suffering from known fertility problems we suggest you discuss the matter with your doctor.

Are there any side-effects?

At the recommended dose of 1 tablet per day, there are no known side-effects.

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